Acute myeloid leukemia is a heterogeneous cancer of the blood and bone marrow. This tumor occurs as a supervene of an over yield of youthful white blood cell which is called myeloblast.
The name of the disease is gotten from the blood cell produced in excess. The youthful white blood cell produced gets into the bone marrow and it's over yield hinders the yield of the general blood cells.
What Is Leukemia
The main cause of the display of these symptoms is as a supervene of the loss of general function of blood by these myelobast. Since they are youthful and sell out the mature and proper functioning blood, their function as blood cells is greatly reduced. One of the functions of blood affected in acute myeloid leukemia is fighting against infection.
Patients with acute myeloid leukemia are de facto infected due to reduced immunity against infection. an additional one very common symptom in patients suffering from acute myeloid leukemia is anemia. Anemia is as a supervene of reduced yield of general red blood cells and platelets. Anemia is commonly severe with different levels of severity seen in different patients. Acute myeloid leukemia has other symptoms like being de facto bruised and having swollen gum, bleeding of the nose, fever, skin pallor and even shortness of breath.
The treatment of acute myeloid leukemia in a newly diagnosed inpatient consist of chemotherapy ( the type of chemotherapy used is age dependent) aimed to speedily induce total remission, when this is achieved, added therapy is then aimed at cure of the disease (by eliminating any undetected residuals of the leukemic cells). Therefore the treatment process is divided into two stages.
The first stage is the stage of induction. The goal of this therapy is to get faultless remission by reducing the quantity of the leukemic cells in the bone marrow and circulating blood to an undetectable level. The commonly used faultless remission induction is a combined chemotherapy of cytarabine and anthracycline. Cytarabine is administered intravenously with dosage of 100 - 200mg/m2/day for one week. Anthracycline consists of daunorubicin is administered intravenously 45-60mg/m2 on day1, 2, and 3.
When induction therapy is completed, the bone marrow is examined. If blast cells are more than 5% with up to 20% cellular cells, induction therapy is performed again with dose similar to the first but cytarabine is given for 5 and antracycline 2 days. But after the second therapy if there is no clear supervene stem cell transplant is considered, though this is only possible in inpatient younger than 65 years.
The second stage is post remission or consolidation therapy, which is aimed at cure of patients with acute myeloid leukemia after the leukemic cells becomes undetectable. In this therapy treatment is based on the patient's condition, this therapy involves an added oppressive chemotherapy of 3 to 5 courses. Patients with high risk of cytogenetics are given allogeneic stem cell transplant. Patients who stem cell transplant is not convenient for, are treated with a mixture therapy of histamine dihydrochloride (ceplene) and interleukin 2.
The treatment of acute myeloid leukemia has shown good prognosis in the time past especially if prognosis is made early ant treatment is started immediately.
medicine Of Acute Myeloid Leukemia - Hanging On To Life
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