Acute Myeloid Leukemia and Benzene

Acute Myeloid Leukemia and Benzene Video Clips. Duration : 2.93 Mins.

www.burke-eisner.com AML (Acute Myeloid Leukemia) is associated with benzene exposure. Benzene is found in petroleum products, and solvents.

Keywords: Benzene AML, acute Myeloid Leukemia, Benzene, solvents

Myeloid Leukemia Definitions, Classifications And Symptoms

Myeloid leukemia is a group of diseases whose characteristic changes are seen in the bone marrow and blood, where tumor cells infiltrate the blood system; sometimes these cells even spill into the circulating blood other tissues. The belief of myeloid leukemia is from the operation of adolescent white blood cells being produced in excess and therefore inhibiting the production of the general blood cells. These cells are called myeloid cells; they by their operation in the blood disturb the function of the blood cells.

This leukemia has both tumors which are kept untreated to those that are diagnosed and treated immediately, fluctuating from rapid fatality to those which are slow in growing. Therefore on the basis of their rehabilitation procedure they are divided into acute myeloid leukemia (Aml) and lasting myeloid leukemia (Cml).

What Is Leukemia

Aml is seen more in men than in women and more prevalent in citizen older than 65 than in citizen of younger age. Cml is also greater in men than in women but its incidence all the time growth slowing and the people's age increases and gets to the peak of occurrence in mid forties from where there is rapid rise in Cml occurrence. Anyway the incidence of Cml decreased slightly in the past two decades.

The etiology of myeloid leukemia is depended on the type, Aml is related with risk factors such as hereditary (other resident blood disease in the family history; Dic) exposure to occupational chemicals, intense exposure to radiation which may be as a follow of therapeutic reasons and even some drugs, but there is nothing relating the cause of Ml to viral infection in any way.

While the etiology of lasting myeloid leukemia has no obvious relation with cytotoxic drug follow and there is also no evidence connecting it with any viral infection, but cigarette smoking by studies has shown to growth its develop into severe crisis, therefore living with lasting myeloid leukemia and smoking becomes dangerous. Only large dosage of radiation has any adverse follow for Cml formation.

The symptoms of Ml are also depending on the type, either it is Aml or Cml. For Aml patients are presented with some nonspecific symptoms which begin either gradually or at once and the symptoms are leucopenia or leucocytosis, thrombocytopenia. These symptoms are commonly due to anemia in such patients. Other symptoms of are fatigue, anorexia and weight loss and nothing else but getting bruised with inordinate bleeding.

While in Cml the symptoms are at first insidious therefore it is difficult to diagnose a patient based but symptoms, such patients are commonly diagnosed during general curative checkup, or others come to the hospital with complaints fatigue, weight loss, symptoms relating to splenomegaly such as early pleasure during eating, left upper quadrant pain, infections, thrombosis or sometimes bleeding.

When lasting myeloid leukemia progresses symptoms worsened with bone and joint pain, requisite loss of weight which will wish addition the dose of the drugs used for treatment. Chemotherapy is used as rehabilitation of myeloid leukemia but when this fails bone transplant is done.

Myeloid Leukemia Definitions, Classifications And Symptoms

medicine Of Acute Myeloid Leukemia - Hanging On To Life

Acute myeloid leukemia is a heterogeneous cancer of the blood and bone marrow. This tumor occurs as a supervene of an over yield of youthful white blood cell which is called myeloblast.

The name of the disease is gotten from the blood cell produced in excess. The youthful white blood cell produced gets into the bone marrow and it's over yield hinders the yield of the general blood cells.

What Is Leukemia

The main cause of the display of these symptoms is as a supervene of the loss of general function of blood by these myelobast. Since they are youthful and sell out the mature and proper functioning blood, their function as blood cells is greatly reduced. One of the functions of blood affected in acute myeloid leukemia is fighting against infection.

Patients with acute myeloid leukemia are de facto infected due to reduced immunity against infection. an additional one very common symptom in patients suffering from acute myeloid leukemia is anemia. Anemia is as a supervene of reduced yield of general red blood cells and platelets. Anemia is commonly severe with different levels of severity seen in different patients. Acute myeloid leukemia has other symptoms like being de facto bruised and having swollen gum, bleeding of the nose, fever, skin pallor and even shortness of breath.

The treatment of acute myeloid leukemia in a newly diagnosed inpatient consist of chemotherapy ( the type of chemotherapy used is age dependent) aimed to speedily induce total remission, when this is achieved, added therapy is then aimed at cure of the disease (by eliminating any undetected residuals of the leukemic cells). Therefore the treatment process is divided into two stages.

The first stage is the stage of induction. The goal of this therapy is to get faultless remission by reducing the quantity of the leukemic cells in the bone marrow and circulating blood to an undetectable level. The commonly used faultless remission induction is a combined chemotherapy of cytarabine and anthracycline. Cytarabine is administered intravenously with dosage of 100 - 200mg/m2/day for one week. Anthracycline consists of daunorubicin is administered intravenously 45-60mg/m2 on day1, 2, and 3.

When induction therapy is completed, the bone marrow is examined. If blast cells are more than 5% with up to 20% cellular cells, induction therapy is performed again with dose similar to the first but cytarabine is given for 5 and antracycline 2 days. But after the second therapy if there is no clear supervene stem cell transplant is considered, though this is only possible in inpatient younger than 65 years.

The second stage is post remission or consolidation therapy, which is aimed at cure of patients with acute myeloid leukemia after the leukemic cells becomes undetectable. In this therapy treatment is based on the patient's condition, this therapy involves an added oppressive chemotherapy of 3 to 5 courses. Patients with high risk of cytogenetics are given allogeneic stem cell transplant. Patients who stem cell transplant is not convenient for, are treated with a mixture therapy of histamine dihydrochloride (ceplene) and interleukin 2.

The treatment of acute myeloid leukemia has shown good prognosis in the time past especially if prognosis is made early ant treatment is started immediately.

medicine Of Acute Myeloid Leukemia - Hanging On To Life

CML (Chronic Myeloid Leukemia) in Macedonia

CML (Chronic Myeloid Leukemia) in Macedonia Video Clips. Duration : 14.95 Mins.

An episode from the Macedonian TV show "Hodnici" which speaks about issues regarding public health in Republic of Macedonia.This episode presents the situation of the people in Macedonia suffering from CML (Chronic Myeloid Leukemia) and their struggle for acquiring the medicine "Glivec", which is not on the reimbursement list of medicines covered by the Macedonian HIF (Health Insurance Fund).Macedonia is the only country in the world where "Glivec" is not reimbursed and all CML patients don't have access to this medicine.

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